HLA-G∗ 14bp insertion and the KIR2DS1-HLAC2 complex impact on behavioral impairment in children with autism spectrum disorders
FR Guerini, E Bolognesi, M Chiappedi, A Ghezzo… - Neuroscience, 2018 - Elsevier
Abstract Activating KIR-HLA-C ligand complexes and HLA-G∗ 14bp insertion/deletion (+/−)
polymorphism were associated to Autism Spectrum Disorders (ASD) and were suggested to
correlate with inflammation during fetal development. We evaluated whether HLA-G∗ 14bp
(+/−) and KIR-HLA-C complexes are associated with cognitive and behavioral scores and
EEG profile in 119 ASD children (58 from Sardinia, 61 from Peninsular Italy). KIR2DS1-C2;
KIR2DS2-C1; KIR2DL1-C2; KIR2DL2-C1; KIR2DL3-C1 and HLA-G∗ 14bp (+/−) were …
polymorphism were associated to Autism Spectrum Disorders (ASD) and were suggested to
correlate with inflammation during fetal development. We evaluated whether HLA-G∗ 14bp
(+/−) and KIR-HLA-C complexes are associated with cognitive and behavioral scores and
EEG profile in 119 ASD children (58 from Sardinia, 61 from Peninsular Italy). KIR2DS1-C2;
KIR2DS2-C1; KIR2DL1-C2; KIR2DL2-C1; KIR2DL3-C1 and HLA-G∗ 14bp (+/−) were …
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